DC 10

PhD Position (m/f/d) Development of a Covered Bioabsorbable Stent-graft Device for Traumatic Aortic Injury Treatment

Project Description

Aortic stent grafts are needed to address aortic aneurysms, which are potentially life-threatening dilations or bulges in the aorta, the body’s main artery. Aneurysms can weaken the arterial wall, increasing the risk of rupture and severe internal bleeding. Aortic stent-grafts serve as a less invasive alternative to traditional open surgery for treating aortic aneurysms. Bioabsorbable aortic stent grafts offer a significant advancement in the treatment of aortic aneurysms, reducing the potential for long-term complications, such as device-related infections or issues with the surrounding tissues. Unlike traditional stent grafts made of permanent materials, bioabsorbable stent grafts are designed to gradually break down and be absorbed by the body over time.

The objectives of this PhD-project are:

1. Generate Design I/O matrix based on clinical inputs and user needs.

2. Develop a computational framework to design a bioabsorbable textile covered stent-graft via FEA. Design optimisation to tailor properties to match aortic compliance.

3. Prototype development using laser-cut or braided graft structure from preferred Mg or Zn alloy and coupling with silk fibroin-based nonwoven by electrospinning with single filament diameter < 30 µm and < 85% porosity.

4. In vitro bench testing of short-term implantation performance and accelerated testing to evaluate long-term degradation performance.

5. Proof-of-concept of late-stage prototype by election for preclinical (animal) testing. This project would suit a candidate with an academic qualification in Mechanical, Biomedical or Materials Engineering (or related disciplines), and previous experience in experimental characterisation or computational modelling of medical devices desirable.

Recruiting partner

University of Galway, Galway, Ireland

PhD enrollment

University of Galway, Galway, Ireland

Secondment host

Fibrothelium GmbH, Aachen, Germany

Lead Supervisors

Prof. Ted Vaughan (Galway)
Dr. Ing. Alexander Kopp (Fibrothelium)

For further details or queries about this project, please contact
BIOMEND@universityofgalway.ie

Interested?

Apply now.